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it is this selectivity that makes the fragment a model tool for studying adipose tissue metabolism Pharmacokinetic profile (based on preclinical models and data for related fragments): Plasma half-life: short, ranging from minutes to hours – typical of short peptides sensitive to proteolysis Oral bioavailability: low – availability after administration through the gastrointestinal tract is limited by peptide degradation Metabolism: hydrolysis of peptide bonds by plasma and tissue peptidases Human PK profile for native fragment 176-191: only partially characterized